Treetop Health provides a referral service to injectable weight loss medications. Click here to learn more: Weight Loss
Glucosamine
Glucosamine is an organic compound found in cartilage––the tough connective tissue that protects joints and bones.
Supplementing with this compound is suggested to help regenerate worn cartilage, providing joint relief and even slowing or reversing joint degeneration.
That said, glucosamine is sometimes derived from shellfish shells. So, if you’re allergic to shellfish, read the ingredient label to learn about the compound’s origin before purchasing.
Chondroitin
Chondroitin sulfate is another organic compound found in cartilage. It’s typically sourced from animal cartilage for supplements. Chondroitin is often paired with glucosamine in joint formulas because the two appear to have synergistic effects.
For instance, chondroitin is suggested to help maintain elasticity in connective tissues. Similar to glucosamine, it could help limit cartilage breakdown and stop joint degradation.
That said, chondroitin is similar to heparin, a blood-thinning medication, and could theoretically enhance its effect. So, it’s recommended not to take supplements containing chondroitin if you also take such medications.
MSM
MSM, also known as methylsulfonylmethane, is an organic compound containing sulfur and is suggested to have antioxidant and anti-inflammatory functions. Taking it may help ease joint discomfort and stiffness, particularly in people with arthritis.
The compound is generally considered safe, with the only listed side effect being mild stomach discomfort.
Turmeric
Turmeric is a spice known for its anti-inflammatory effects. Research on patients with osteoarthritis suggests that turmeric supplementation may help ease joint pain and improve knee range of motion.
This spice is not associated with any side effects. Still, some of its active ingredients (including curcumin, more on that next) are not as bioavailable, meaning the body may not absorb them as effectively.
Curcumin
As briefly mentioned above, curcumin is one of the active ingredients in turmeric. It’s largely responsible for its distinctive yellow color and many of the associated health benefits.
It has a strong antioxidant and anti-inflammatory profile and is often recommended to people with joint pain.
Curcumin is often paired with BioPerine (more on it next) to improve bioavailability and absorption.
BioPerine
BioPerine is a patented extract of piperine (the bioactive ingredient in black pepper) that’s often added to supplements to improve the absorption of various compounds.
Some research suggests that BioPerine can improve curcumin’s absorption by a whopping 2000%. It’s also suggested to improve the absorption of selenium, a mineral with anti-inflammatory and antioxidant properties,
In addition to boosting the absorption of other compounds with a favorable impact on joint health, BioPerine is suggested to help control inflammation, making it a great addition to joint complexes.
Boswellia
Boswellia (also known as Indian frankincense) is a herb extract from the Boswellia serrata tree used in Asian and African medicine for centuries.
The extract possesses anti-inflammatory effects and can have a favorable impact on joint health, with studies on patients with osteoarthritis and rheumatoid arthritis showing promising results.
Thanks to its effects, it may help ease joint discomfort and improve joint range of motion and mobility. It may also slow or stop the loss of cartilage.
That said, boswellia extract may interact with anti-inflammatory medications, so it’s best to consult your doctor if you’re taking any.
Resveratrol
Resveratrol is a natural compound primarily found in red grapes and products made from them––namely, red wine. The compound is linked to various positive health effects, such as expanding blood vessels and reducing the risk of blood clots.
Additionally, the compound possesses anti-inflammatory effects and may help reduce joint inflammation, easing pain and discomfort.
Research also suggests that resveratrol may limit bone and cartilage damage, as well as reduce proteoglycan loss (a type of protein found in high concentrations in connective tissues; it plays a crucial role in allowing tissues and joints to withstand external forces).
The only potential drawback is that higher doses of resveratrol may interact with blood-thinning medication.
Collagen (all types)
Collagen is the most abundant protein in the body, accounting for nearly a third of the total protein mass. It’s found in skeletal muscle, organs, skin, bones, joints, and connective tissues (e.g., ligaments and tendons).
In the context of joint health, collagen plays a crucial structural role, essentially functioning as the glue that keeps everything together. Research suggests that supplementation can ease symptoms of osteoarthritis.
There are at least 16 types of collagen, but the most important ones for joint health are types I, II, III, and V.
For instance, type I collagen is the main structural component of cartilage, which protects the bones by allowing friction-free movement at the joints. Supplementing with types I and II may help rebuild cartilage and reduce joint inflammation.
Boron
Boron is a trace mineral with numerous beneficial effects on joint and bone health.
For one, this mineral has been shown to help reduce levels of inflammation-promoting enzymes as well as raise levels of antioxidant enzymes that protect cells from oxidative stress.
These effects help control inflammation and ease joint stiffness and discomfort.
Second, boron appears to play an important role in bone formation, and deficiencies in the mineral are associated with reduced bone mineral density and a higher risk of joint injuries.
It’s recommended not to consume more than 20 mg of boron daily. Higher amounts can sometimes lead to gastrointestinal discomfort.
Hyaluronic Acid
Hyaluronic acid is a substance naturally found in synovial fluid––the clear, viscous liquid found in the cavities of joints that serves as a lubricant and shock absorber.
Adequate intake and production of hyaluronic acid is crucial for the optimal, friction-free movement of the joints.
Supplementation with the substance has been associated with joint relief and improved range of motion in patients with osteoarthritis.
Beef Bone and Marrow
Beef bone and marrow are rich in collagen, minerals, and marrow fat, all of which support joint health in some way. Most notably, supplements containing these ingredients can provide the building blocks needed to regenerate cartilage and strengthen the bones.
Both products are safe to take and have no known side effects.
Mussel oil
Mussels are an excellent source of omega-3 fatty acids, which are known and praised for their anti-inflammatory effects.
Oil derived from mussels is also an excellent source of these fatty acids, as well as eicosatetraenoic acid (ETA), which further contributes to the anti-inflammatory effects and positive impact on joint health.
Experts suggest that mussel oil may help relieve symptoms associated with arthritis.
Three Supplement Complexes For Joint Health (+2 Unique Outliers)
Complex 1: Glucosamine, Chondroitin, MSM, Turmeric, and Boswellia
The first complex features the following active ingredients:
- Glucosamine Sulfate with Potassium (GS-K)
- Boswellia Extract
- Chondroitin Sulfate
- Turmeric Extract
- Quercetin
- L-Methionine
- MSM (Methylsulfonylmethane)
- Bromelain
- Hyaluronic Acid
- Vitamin D3
This mix of natural compounds (including vitamins and minerals) provides nuanced joint support. In addition to their unique functions, these compounds also work together and build upon each other to improve cartilage health and strength, inflammation, joint mobility, and subjective feelings of discomfort.
Products (with Active links)
- Glucosamine Chondroitin MSM Turmeric Boswellia – the standard bottle has 90 unflavored capsules (30-day supply). Users love the pain relief, the fact that it’s all organic, and the ease of consuming the capsules.
- Glucosamine Chondroitin Turmeric MSM Boswellia – the standard amount is 180 capsules (60-day supply). A recurring theme among satisfied customers is the product’s positive impact on joint comfort and mobility.
- Nature Made Glucosamine Chondroitin Complex with MSM – the standard amount is 120 capsules (60-day supply). People love the positive impact on joint comfort and range of motion.
- Doctor’s Best Glucosamine Chondroitin Msm with OptiMSM Capsules – the standard bottle has 120 capsules (30-day supply). Users love the positive impact on joint pain and mobility.
- Move Free Advanced Glucosamine Chondroitin MSM Joint Support Supplement – the standard bottle has 120 capsules (40-day supply). Happy customers praise the product for the pain relief and how it makes everyday activities such as walking easier.
- Nature’s Way Joint Movement Glucosamine Fast Absorbing Liquid – the standard bottle has 16 fluid ounces (16-day supply). Customers love the positive effects and praise the product for the quick joint relief it provides.
- Osteo Bi-Flex Triple Strength Glucosamine with Turmeric – the standard serving is 80 capsules (40-day supply). A recurring theme among reviews is how effectively this supplement relieves joint discomfort and swelling.
Complex 2: Curcumin Turmeric | Curcuminoids & BioPerine Black Pepper Extract
The second complex has the following active ingredients:
- Turmeric
- BioPerine
- Ginger Extract
- Curcuminoids
It primarily focuses on the compounds’ antioxidant and anti-inflammatory effects to support joint health. The combination is particularly beneficial for controlling inflammatory markers, which can help ease joint swelling and discomfort while improving range of motion and functionality.
Additionally, some of the ingredients, like BioPerine, can improve the absorption of turmeric.
Products (with active links)
- NatureWise Curcumin Turmeric – the standard bottle has 90 capsules (30-day supply). Customers praise the product’s quality and organic status, as well as for the pain relief.
- Turmeric Curcumin with Black Pepper Extract – the standard amount is 90 capsules (30-day supply). Customers love how easy the capsules are to swallow and appreciate the positive impact on joint comfort and everyday activities.
- Qunol Turmeric Curcumin with Black Pepper & Ginger – the standard bottle has 105 capsules (35-day supply). Customers like the product’s positive impact on arthritis and pain.
- Turmeric Curcumin with BioPerine & Ginger – the standard amount is 240 capsules per bottle (80-day supply). People like the joint relief and ease of swallowing.
- THORNE Curcumin Phytosome 1000 mg (Meriva) – the standard amount is 120 capsules (60-day supply). People praise the price per serving and love the positive impact on inflammation and joint discomfort.
Complex 3: Types I, II, and III Collagens, Boron & Hyaluronic Acid
The third and final complex has the following active ingredients:
- Type I, II, and III Collagen
- Hyaluronic Acid
- Boron
- Chondroitin
- MSM
Unlike the previous complex, this one focuses on improving the structural integrity of the joints and other surrounding tissues. It also supports joint lubrication for friction-free movement and has a positive impact on bone health.
For instance, collagen has a profound positive impact on connective tissue health and elasticity. In contrast, hyaluronic acid is a key ingredient in synovial fluid, which lubricates the joints and acts as a shock absorber.
Products (with active links)
- Move Free Ultra Triple Action Joint Support Supplement – Type II Collagen Boron & Hyaluronic Acid – the standard bottle has 64 capsules (64-day supply). People love how easy the capsules are to swallow and how much they improve joint mobility and comfort.
- Vital Vitamins Collagen for Women & Men – there are 150 capsules per bottle (50-day supply). People like the performance-enhancing effects and improved joint comfort.
- Klaire Labs Joint Revitalizer – Patented Hydrolyzed Collagen Peptide Formula with Chondroitin, MSM & Hyaluronic Acid – there are 120 capsules per bottle (60-day supply). Folks with rheumatoid arthritis praise the product for its positive impact on symptoms like joint pain.
- Sports Research Collagen Peptides for Women & Men – Hydrolyzed Type 1 & 3 Collagen Powder Protein – the standard amount is 454 grams (41-day supply). Customers like how easily it dissolves and mixes, that it has a neutral taste, and that it supports joint health.
two Unique Outliers
1. Beef Bone and Marrow Supplement
Made from a blend of bone matrix, marrow, and cartilage and sourced from grass-fed beef, each capsule delivers a wide range of nutrients that support joint, connective tissue, and bone health.
While the product focuses on whole-body health, it provides stem cells, collagen, and growth factors that support repair processes within the body.
Users love the wide range of benefits, particularly how the product promotes joint comfort and mobility.
This product is a distinct addition (or even replacement) for traditional omega-3 fatty acids delivered from fish oil. The active ingredients are derived from green-lipped mussel oil and include the popular omega-3’s EPA and DHA, as well as approximately 30 other kinds.
Additionally, lipid mediators in this formula contribute to joint and muscle health. Along with omega-3s, these organic compounds help control inflammation.
Happy customers praise the product for its positive impact on joint mobility, particularly in the knees. Additionally, users report reduced back pain and greater joint comfort.
Conclusion
So, there we have it. The above are some of the most important active ingredients to look for in any joint formula.
They’ve been shown to improve mobility and reduce pain in multiple ways, including by controlling inflammation and supporting the structural integrity of cartilage and connective tissues surrounding joints.
That said, it’s always best to do independent research and pick a product you trust to help in your unique situation. Our primary goal with this comparison article was to educate you on the active ingredients, how they work, and how they (sometimes) interact with one another.